Pharmacogenomics aims to rationalize drug use by minimizing drug toxicity and/or by increasing drug efficacy. A large number of genomic variants have been correlated with variable drug response and severity of adverse drug reactions. Although a fraction of these drugs have been approved by regulatory agencies and comprehensive drug-gene lists exist online, information related to the respective pharmacogenomic biomarkers is currently missing from such lists. We have extracted information from the published literature and online resources and developed DruGeVar, an online database triangulating drugs with genes and pharmacogenomics biomarkers in an effort to build a comprehensive database that could serve clinical pharmacogenomics. A user-friendly data querying and visualization interface allows users to formulate simple and complex queries. Such database would be readily applicable as a stand-alone resource or a plug-in module for other databases.
